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Method for scrubbing exhaust gas from CO2 and/or SOx
Publication number: 20220152554
Abstract: A method of exhaust gas scrubbing includes providing recycled concrete fines as a waste material rich in carbonatable Ca and/or Mg phases and with d90?1000 ?m and a Rosin-Rammler slope n from 0.6 to 1.4 , injecting the waste material into an exhaust gas stream containing CO2 and/or SOx for reaction with CO2 and/or SOx at a relative humidity of 50 to 100 Vol.-% and a temperature from 40 to 130° C. in an amount of dry waste material ranging from 5 to 30 kg/m3, withdrawing a partly carbonated and/or sulphurized waste material and purified exhaust gas, and recycling a part of the partly carbonated and sulphurized waste material while the remainder is discharged, as well as use of a waste material slurry for exhaust gas cleaning of CO2 and/or SOx.
Type: Application
Filed: June 4, 2020
Publication date: May 19, 2022
Applicant: HConnect 2 GmbH
Inventors: Jan SKOCEK, Maciej ZAJAC, Mohsen BEN HAHA, Stefan FEDERHEN
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USE OF INHIBITORS OF YAP AND SOX2 FOR THE TREATMENT OF CANCER
Publication number: 20220280590
Abstract: Methods of inducing apoptosis and inhibiting proliferation in YAP-dependent cancer cells, involving contacting the cells with one or more inhibitors of YAP and one or more inhibitors of SOX2. In addition, methods of treating or preventing YAP-dependent cancer in subjects, involving administering to the subject one or more inhibitors of YAP and one or more inhibitors of SOX2.
Type: Application
Filed: August 20, 2020
Publication date: September 8, 2022
Applicant: Georgetown University
Inventors: Chunling Yi, Shigekazu Murakami
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METHODS OF INDUCING PLURIPOTENCY INVOLVING SOX2 PROTEIN
Publication number: 20110190729
Abstract: The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof. The invention also relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises removing from the mammal one or more responsive cells and culturing the cells in a suitable medium, introducing into the cells an effective amount of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof and subsequently returning the cells to the patient. In a further embodiment the invention relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises introducing into responsive cells of the mammal an effective amount of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof.
Type: Application
Filed: November 28, 2008
Publication date: August 4, 2011
Applicant: CYTOMATRIX PTY LTD
Inventors: Mark Alexander Kirkland, Tamara Jane Gough
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Novel Suicidal LSD1 Inhibitors Targeting SOX2-Expressing Cancer Cells
Publication number: 20160120862
Abstract: Disclosed are inhibitors of lysine-specific demethylase I (LSD1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating cancers characterized by the presence of Sox2 using the compounds and compositions Also disclosed are methods of treating cancers characterized by the presence of Sox2 using inhibitors of LSD1 and/or histone deacetylation I (HDAC1). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type: Application
Filed: May 30, 2014
Publication date: May 5, 2016
Inventor: Hui Zhang
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Suicidal LSD1 inhibitors targeting SOX2-expressing cancer cells
Patent number: 9918983
Abstract: Disclosed are inhibitors of lysine-specific demethylase I (LSD1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating cancers characterized by the presence of Sox2 using the compounds and compositions Also disclosed are methods of treating cancers characterized by the presence of Sox2 using inhibitors of LSD1 and/or histone deacetylation I (HDAC1). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type: Grant
Filed: May 30, 2014
Date of Patent: March 20, 2018
Assignee: THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS
Inventor: Hui Zhang
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GENERATION OF INDUCED PLURIPOTENT STEM CELLS WITH POLYCISTRONIC SOX2, KLF4, AND OPTIONALLY C-MYC
Publication number: 20220372447
Abstract: Described herein a polycistronic expression cassettes and expression vectors that include a promoter operably linked to a nucleic acid segment that encodes a Sox2 and Klf4 polypeptide. The nucleic acid segment can also encode a c-Myc polypeptide. Expression of such polycistronic expression cassettes/vectors in host cells can reprogram the host cells to stem cells or other types of reprogrammed cells.
Type: Application
Filed: October 16, 2020
Publication date: November 24, 2022
Inventors: Peng LIU, Sheng DING
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SCREENING DEVICE CONTAINING NANOG PROMOTER, SOX2 PROMOTER, LIN 28 PROMOTER, OCT4 PROMOTER AND LUCIFERASE GENE AND SCREENING METHOD THEREOF
Publication number: 20130004959
Abstract: A screening device that contains Nanog promoter, Sox2 promoter, Lin28 promoter, Oct4 promoter and luciferase gene and a method thereof is revealed. The screening device is used to find out small molecules that improve activity of the promoters mentioned-above. A reporter plasmid formed by a pStable vector is introduced into stable somatic cells or stem cells with reporter plasmids such as a C2C12 mouse myoblast cell line and a P19 embryonal carcinoma cell line. By the luciferase gene contained in the pStable vector and pluripotent gene promoters placed upstream of the luciferase gene, luciferase expression is assayed by luminescence intensity measured. Thus response and activity of the promoters placed upstream of the luciferase gene is measured and small molecules inducing pluripotency are found out. If a drug can activate all promoters or respective promoter, it can be used as a drug that induces cell pluropatency.
Type: Application
Filed: January 3, 2012
Publication date: January 3, 2013
Applicant: NATIONAL CENTRAL UNIVERSITY
Inventors: Shen Laing CHEN, Wei Jhen HUANG, Moo Rung LOO
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METHOD FOR REPROGRAMMING OF HUMAN DENTAL PULP CELL USING OCT4 AND SOX2 AND USE THEREOF
Publication number: 20150299665
Abstract: The present invention relates to a method for producing endothelial progenitor cells, comprising a method for producing induced pluripotent stem cells by using only Oct4 and Sox2 as a reprogramming factor of human dental pulp cells, and differentiating endothelial progenitor cells from the induced pluripotent stem cells produced by the method for producing induced pluripotent stem cells. Moreover, the present invention relates to a method for producing endothelial cells, comprising differentiating endothelial cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells. Additionally, the present invention relates to a method for producing smooth muscle cells, comprising differentiating smooth muscle cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells.
Type: Application
Filed: July 25, 2014
Publication date: October 22, 2015
Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
Inventors: Yee Sook Cho, Chae Wha Yoo, Hee Jun Na
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Method for reducing CO2, CO, NOX, and SOx emissions
Patent number: 6447437
Abstract: Industrial combustion facilities are integrated with greenhouse gas-solidifying fertilizer production reactions so that CO2, CO, NOx, and SOx emissions can be converted prior to emission into carbonate-containing fertilizers, mainly NH4HCO3 and/or (NH2)2CO, plus a small fraction of NH4NO3 and (NH4)2SO4. The invention enhances sequestration of CO2 into soil and the earth subsurface, reduces N03− contamination of surface and groundwater, and stimulates photosynthetic fixation of CO2 from the atmosphere. The method for converting CO2, CO, NOx, and SOx emissions into fertilizers includes the step of collecting these materials from the emissions of industrial combustion facilities such as fossil fuel-powered energy sources and transporting the emissions to a reactor. In the reactor, the CO2, CO, N2, SOx, and/or NOx are converted into carbonate-containing fertilizers using H2, CH4, or NH3.
Type: Grant
Filed: March 31, 2000
Date of Patent: September 10, 2002
Assignee: UT-Battelle, LLC
Inventors: James Weifu Lee, Rongfu Li
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MUTANT SOX PROTEINS AND METHODS OF INDUCING PLURIPOTENCY
Publication number: 20120220029
Abstract: There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
Type: Application
Filed: November 4, 2010
Publication date: August 30, 2012
Applicant: Agency for Science, Technology and Research
Inventors: Prasanna R. Kolatkar, Irene Aksoy, Ralf Jauch, Lawrence W. Stanton
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Mutant sox proteins and methods of inducing pluripotency
Patent number: 8907055
Abstract: There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
Type: Grant
Filed: November 4, 2010
Date of Patent: December 9, 2014
Assignee: Agency for Science, Technology and Research
Inventors: Prasanna R. Kolatkar, Irene Aksoy, Ralf Jauch, Lawrence W. Stanton
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SOx trap for diesel and lean-burn gasoline automotive applications
Publication number: 20050145827
Abstract: The present invention provides a regenerable catalyst composition suitable for entrapping SOx. The composition of the invention comprises a copper oxide having the formula (Cu/(A oxide) where A oxide is SiO2, Zr—SiO2, A12O3, TiO2—Al2O3, ZrO2 and In2O3 or mixtures thereof. Copper loading may vary from about 10 to 60 mol % and is preferably about 25 mol %. The catalyst composition adsorbs SOx as metal sulfate under lean conditions and desorbs accumulated SOx as SO2 under rich conditions. Such reversible SOx trap are able to operate under conventional NOx trap operating conditions to prevent sulfur poisoning of the NOx trap. Furthermore, these traps may be regenerated under rich conditions at 300-450° C. In another embodiment of the present invention, an irreversible SOx trap capable of collecting SOx under lean conditions is provided. The traps of this embodiment include praseodymia, zirconia-praseodymia and mixed manganese-yttria and mixtures thereof.
Type: Application
Filed: December 30, 2003
Publication date: July 7, 2005
Inventors: Robert McCabe, Woosang Chun, George Graham, Clifford Montreuil, Brendan Carberry, Albert Chigapov, Alexei Dubkov
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SOx CAPTURE USING CARBONATE ABSORBENT
Publication number: 20220134279
Abstract: A desulfurization gas process includes water vapor, CO2 and SOx (x=2 and/or 3). In a treatment unit, the gas contacts a cooled alkaline aqueous solution having a temperature lower than an initial gas temperature, water and a carbonate of an alkali metal, to cool the gas, condense some water vapor and absorb SOx in the carbonate-containing solution, produce an SOx-depleted gas and an acidic aqueous solution including sulfate and/or sulfite ions. The SOx-depleted gas and a portion of the acidic aqueous solution can then be withdrawn from the treatment unit. Carbonate of the alkali metal can be added to remaining acidic aqueous solution to obtain a made-up alkaline aqueous solution. This solution can be cooled and reused as the cooled alkaline aqueous solution. An SOx absorbent solution includes a bleed stream from a CO2-capture process, sodium or potassium carbonate, and an acidic aqueous solution obtained from desulfurization.
Type: Application
Filed: November 12, 2021
Publication date: May 5, 2022
Applicant: SAIPEM S.P.A.
Inventors: Sylvain LEFEBVRE, Richard SURPRENANT, Ferrere CLERVEAUX, Gabriel VEILLEUX, David ZHANG
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SOx CAPTURE USING CARBONATE ABSORBENT
Publication number: 20200368679
Abstract: A desulfurization gas process includes water vapor, CO2 and SOx (x=2 and/or 3). In a treatment unit, the gas contacts a cooled alkaline aqueous solution having a temperature lower than an initial gas temperature, water and a carbonate of an alkali metal, to cool the gas, condense some water vapor and absorb SOx in the carbonate-containing solution, produce an SOx-depleted gas and an acidic aqueous solution including sulfate and/or sulfite ions. The SOx-depleted gas and a portion of the acidic aqueous solution can then be withdrawn from the treatment unit. Carbonate of the alkali metal can be added to remaining acidic aqueous solution to obtain a made-up alkaline aqueous solution. This solution can be cooled and reused as the cooled alkaline aqueous solution. An SOx absorbent solution includes a bleed stream from a CO2-capture process, sodium or potassium carbonate, and an acidic aqueous solution obtained from desulfurization.
Type: Application
Filed: August 10, 2018
Publication date: November 26, 2020
Applicant: SAIPEM S.P.A.
Inventors: Sylvain LEFEBVRE, Richard SURPRENANT, Ferrere CLERVEAUX, Gabriel VEILLEUX, David ZHANG
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Method for scrubbing exhaust gas from CO and/or SO
Patent number: 11642625
Abstract: A method of exhaust gas scrubbing includes providing recycled concrete fines as a waste material rich in carbonatable Ca and/or Mg phases and with d90?1000 ?m and a Rosin-Rammler slope n from 0.6 to 1.4 , injecting the waste material into an exhaust gas stream containing CO2 and/or SOx for reaction with CO2 and/or SOx at a relative humidity of 50 to 100 Vol.-% and a temperature from 40 to 130° C. in an amount of dry waste material ranging from 5 to 30 kg/m3, withdrawing a partly carbonated and/or sulphurized waste material and purified exhaust gas, and recycling a part of the partly carbonated and sulphurized waste material while the remainder is discharged, as well as use of a waste material slurry for exhaust gas cleaning of CO2 and/or SOx.
Type: Grant
Filed: June 4, 2020
Date of Patent: May 9, 2023
Assignee: HConnect 2 GmbH
Inventors: Jan Skocek, Maciej Zajac, Mohsen Ben Haha, Stefan Federhen
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Method of Preparing Induced Neural Stem Cells Reprogrammed from Non-Neuronal Cells Using HMGA2
Publication number: 20160215259
Abstract: The present invention relates to a method of preparing induced neural stem cells which are reprogrammed from differentiated cells. The method of producing the induced neural stem cells according to the present invention enables preparation of the induced neural stem cells from non-neuronal cells using only two inducing factors of SOX2 and HMGA2. Therefore, the method of the present invention can prepare induced neural stem cells in a more efficient manner than the conventional methods, which use four or five inducing factors. Additionally, the method of the present invention shows significantly higher inducing efficiency and proliferation capacity than when only a single SOX2 gene is used, thus increasing its potency to be used for therapeutic purposes.
Type: Application
Filed: April 4, 2014
Publication date: July 28, 2016
Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors: Kyung Sun Kang, Kyung Rok Yu
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Method of preparing induced neural stem cells reprogrammed from non-neuronal cells using HMGA2
Patent number: 11512285
Abstract: The present invention relates to a method of preparing induced neural stem cells which are reprogrammed from differentiated cells. The method of producing the induced neural stem cells according to the present invention enables preparation of the induced neural stem cells from non-neuronal cells using only two inducing factors of SOX2 and HMGA2. Therefore, the method of the present invention can prepare induced neural stem cells in a more efficient manner than the conventional methods, which use four or five inducing factors. Additionally, the method of the present invention shows significantly higher inducing efficiency and proliferation capacity than when only a single SOX2 gene is used, thus increasing its potency to be used for therapeutic purposes.
Type: Grant
Filed: April 4, 2014
Date of Patent: November 29, 2022
Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, KANGSTEM BIOTECH CO., LTD.
Inventors: Kyung Sun Kang, Kyung Rok Yu
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COMPOSITIONS COMPRISING STEM CELLS EXPRESSING MESENCHYMAL AND NEURONAL MARKERS AND USES THEREOF TO TREAT NEUROLOGICAL DISEASE
Publication number: 20220193141
Abstract: The present disclosure relates to a cryopreserved pharmaceutical composition comprising immature dental pulp stem cells (IDPSCs) expressing SOX-1 and SOX-2 and methods of treating a neurological disease or condition comprising systemically administering to a subject a cryopreserved pharmaceutical composition comprising IDPSCs expressing SOX-1 and SOX-2.
Type: Application
Filed: December 27, 2021
Publication date: June 23, 2022
Inventors: Irina Kerkis, Alexandre Kerkis
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Method for Removing SOx from Gas with Modified Polyethylene Glycol
Publication number: 20160220946
Abstract: A method for removing SOx from a gas by using a modified polyethylene glycol solution to absorb the SOx in the gas. The modified polyethylene glycol solution is contacted with the gas containing SOx to absorb the SOx in the gas, wherein x=2 and/or 3, the modified polyethylene glycol is a product derived from etherifying hydroxyl groups in the molecules of ethylene glycol and/or polyethylene glycol and has a general formula: R1—(O—C2H4)n—O—R2, where n is a positive integer, R1 and R2 are the same or different and are each independently alkyl, alkenyl, alkynyl, acyl or aryl.
Type: Application
Filed: September 4, 2014
Publication date: August 4, 2016
Inventors: Xionghui WEI, Shaoyang SUN, Meihua ZOU, Jianbai XIAO, Lifang LI, Li CHEN, Chun HU, Xiangbin LI, Mingjin WAN
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METHOD FOR PREPARING INDUCED PLURIPOTENT STEM CELL, COMPOSITION USED IN METHOD, AND USES THEREOF
Publication number: 20170037376
Abstract: Provided are a method for preparing an induced pluripotent stem cell and a composition used in the method. The method comprises: introducing a composition for promoting the formation of an induced pluripotent stem cell into a somatic cell, the composition comprising: (i) a c-Jun antagonist and one group of factors from among the following seven such groups: (1) Sox2, Klf4 and c-Myc, (2) Klf4 and c-Myc, (3) Oct3/4, Klf4 and c-Myc, (4) Sox2, Nanog and Lin28, (5) Oct3/4, Nanog and Lin28, (6) Oct3/4, Klf and Sox2, and (7) Klf4 and Sox2; or (ii) the c-Jun antagonist, Jhdm1b and Id1, and at least one of Glis1, Sall4 or Lrh1; or (iii) the c-Jun antagonist, Jhdm1b and Id1, and at least one of: Oct4, Klf4, Sox2, Lin28, Esrrb, Lef1, Utf1 or miRNA C. The present method allows for successful preparation of induced pluripotent stem cells with no generation of abnormal chromosomes.
Type: Application
Filed: November 12, 2014
Publication date: February 9, 2017
Applicant: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES
Inventors: Duanqing PEI, Jing LIU, Jiekai CHEN, Meixiu PENG
